Untangling the Data: pTau and Neurofibrillary Tangles as Part of Early Alzheimer’s Detection

Statement of Need

Alzheimer’s disease (AD) presents a growing challenge in contemporary health care, with escalating prevalence and a significant burden imposed on patients, families, and health care systems globally. Early and accurate diagnosis of AD is essential for effective support and treatment. However, many clinicians may not realize the importance of early diagnosis or understand the utility of new biomarker tests for AD pathology.

In this first installment of a two-part Journal Club series, An Expanded View of Alzheimer’s Disease Neuropathology: Translation to the Early Identification of Disease, expert faculty will present the latest information on the neuropathological changes associated with AD, their relevance to the cognitive and functional decline of early AD, as well as the role of phosphorylated tau biomarkers as early indicators of both amyloid and tau accumulation.

Learning Objectives

At the conclusion of this activity, learners will be able to better:

Identify the neuropathological changes associated with AD, including those occurring downstream of amyloid accumulation, and their relevance to the cognitive and functional decline of early AD
Assess the role of phosphorylated tau biomarkers as early indicators of both amyloid and tau accumulation

Financial Support

This activity is supported by an educational grant from Lilly.

Target Audience

Physicians, physician associates (PAs), and nurse practitioners (NPs) specializing in dementia, psychiatry, neurology, or geriatrics

Credit Information

Jointly Accredited Provider

In support of improving patient care, CME Outfitters, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians (ACCME) 0.5

CME Outfitters, LLC, designates this Enduring Material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Note to Nurse Practitioners: Nurse practitioners can apply for AMA PRA Category 1 CreditTM through the American Academy of Nurse Practitioners (AANP). AANP will accept AMA PRA Category 1 CreditTM from Jointly Accredited Organizations. Nurse practitioners can also apply for credit through their state boards.

Note to Physician Associates: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit ™ from organizations accredited by the Accreditation Council for Continuing Medical Education.

ABIM MOC 0.5

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 medical knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

UEMS-EACCME®

Through a mutual recognition agreement between the AMA and the UEMS-EACCME, European physicians completing an e-learning activity from a US-based ACCME-accredited CME provider can use AMA PRA Category 1 Credit™ toward their credit requirements. CME Outfitters is based in Radnor, Pennsylvania, USA. Please retain your certificate as proof of completion.

Disclosure Declaration

Dr. Mattsson-Carlgren reports no financial relationships to disclose.

The following individuals have no financial relationships to disclose:

Thomas Heinrich, MD (Peer Reviewer)
Evan Luberger (Planning Committee)
Kellie Busby, PharmD, BCPP (Planning Committee)
Erin Spencer (Planning Committee)
Susan H. Yarbrough, CHCP (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (70% pass rate required). This website supports all browsers except Internet Explorer for Mac.

Questions about this activity?

Call us at 877.CME.PROS (877.263.7767).

JC-028-021224-11

Untangling the Data: pTau and Neurofibrillary Tangles as Part of Early Alzheimer’s Detection

Faculty

Statement of Need

Learning Objectives

Financial Support

Target Audience