Versatility of Therapeutic uses of Costimulation Blockade in Kidney Transplantation

Faculty

Flavio G. Vincenti, MD
Transplant Nephrologist
UCSF Medical Center
Professor of Clinical Medicine
University of California San Francisco
San Francisco, CA

Statement of Need

Despite advances in immunosuppressive therapy that have greatly extended survival for kidney graft recipients, challenges related to long-term implementation remain. Use of immunosuppressants is limited by their narrow therapeutic index, large intra- and inter-individual variability in pharmacokinetics, and drug-related toxicity, rendering selection of the optimal treatment path challenging. Balancing the risks of graft rejection with the consequences of drug-related toxicities remains a primary challenge among health care practitioners (HCPs) managing kidney transplant recipients, particularly in the long-term maintenance setting.

In this CME Outfitters recorded Grand Rounds series entitled, Versatility of Therapeutic uses of Costimulation Blockade in Kidney Transplantation, expert faculty will discuss strategies for identifying optimal immunosuppressive regimens, developing individualized management plans for patients who fail initial immunosuppressive therapy, and counseling patients with renal transplant on long-term immunosuppressive therapy.

Learning Objectives

At the conclusion of this activity, learners will be able to better:

  • Identify the optimal maintenance immunosuppressive regimen for each individual renal transplant recipient based on available safety and efficacy data
  • Develop individualized management plans for patients who fail initial immunosuppressive therapy to sustain long-term graft survival
  • Counsel patients with renal transplant on long-term immunosuppressive therapy, emphasizing the balance between short- and long-term goals

Financial Support

Supported by an educational grant from Bristol Myers Squibb.

Target Audience

U.S. and ex-US* surgical nephrologists/transplant surgeons, community and academic nephrologists, nurse practitioners (NPs), physician associates (PAs), nurses, and pharmacists.

Credit Information

Jointly Accredited Provider

In support of improving patient care, CME Outfitters, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Physicians (ACCME) 1.0

CME Outfitters, LLC, designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Pharmacists (ACPE) 1.0

This application-based activity is approved for 1.00 contact hours (0.1 CEUs) of continuing pharmacy credit (JA0007185-0000-24-078-H01-P).

Nurses (ANCC) 1.0

This activity is designated for 1.00 contact hours.

California Residents: This continuing nursing education activity was approved by the California Board of Registered Nursing. CME Outfitters, LLC’s provider number is CEP15510.

Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology.

Interprofessional (IPCE) 1.0

This activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education Credit for learning and change.

Physician Assistants (AAPA): 1.0

CME Outfitters, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credits. Approval is valid until 10/04/2025. PAs should only claim credit commensurate with the extent of their participation.

ABIM MOC 1.0

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

UEMS-EACCME®

Through a mutual recognition agreement between the AMA and the UEMS-EACCME, European physicians completing an e-learning activity from a US-based ACCME-accredited CME provider can use AMA PRA Category 1 Credit™ toward their credit requirements. CME Outfitters is based in Radnor, Pennsylvania, USA. Please retain your certificate as proof of completion.

Disclosure Declaration

Dr. Vincenti reports the following financial relationships:

Advisory Board: Alexion Pharmaceuticals, Inc. and eGenesis

Consultant: Bristol Myers Squibb Company; Eledon Pharmaceuticals, Inc.; Mallinckrodt Pharmaceuticals; Merck & Co., Inc.; and Veloxis Pharmaceuticals, Inc.

Grants and Research Support: Angion; Eledon Pharmaceuticals, Inc.; Horizon Therapeutics; Merck & Co., Inc.; Regeneron Pharmaceuticals Inc.; and Sanofi

The following individuals have no financial relationships to disclose: 

Jeffrey Helfand, DO (Peer Reviewer)
Albert Eubanks, Jr., RN (Peer Reviewer)
Evan Luberger (Planning Committee)
John Jones, PharmD (Planning Committee)
Scott J. Hershman, MD, FACEHP, CHCP (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

Questions about this activity?

Call us at 877.CME.PROS (877.263.7767).

GRV-044-100424-08

Versatility of Therapeutic uses of Costimulation Blockade in Kidney Transplantation
Event Date: 10/04/2024