Precision and Rescue Medicine in Brain Aging Diseases | November 29, 2022

Which of the following statements is true regarding brain pathology and clinical features in patients with parkinsonism?*
- Those who are clinically diagnosed with Parkinson's disease only have nigral neuronalloss and Lewy bodies on brain pathology.
- Those who are clinically diagnosed with parkinsonism will have pathologic features ofParkinson's disease and/or one of the atypical parkinsonisms.
- The average individual with parkinsonism, with and without a clinicaldiagnosis of Parkinson's disease, will have a median of three pathologies.
- Nigral neuronal loss and Lewy bodies are not seen in those without parkinsonism.
Which of the following statements is true regarding LRRK2 mutations?*
- An individual with a known pathologic (PD-causing) mutation in the LRRK2 gene willalways develop parkinsonism.
- Known pathologic (PD-causing) mutations in the LRRK2 gene will give rise to asynucleinopathy only.
- Known pathologic (PD-causing) mutations in the LRRK2 gene can give rise tomultiple pathologies.
- Alpha-synuclein aggregation is necessary for parkinsonism to occur.
Which of the following statements is true regarding our current understanding of Parkinson's disease?*
- Data and studies have proven that Parkinson's disease is a homogenous entity.
- Disease-modifying trials have been relatively successful in the past few years.
- Our current method of diagnosing PD clinically is accurate and reflects pathologyresults.
- 'Parkinson's disease' is likely representative of multiple diseases with manyetiopathogeneses that have yet to be uncovered

Precision and Rescue Medicine in Brain Aging Diseases | November 29, 2022

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